Untangling the interplay between modifiable and non-modifiable risk factors – genetics, epigenetics, diet, lifestyle, and environment – is central to our understanding of the onset and progression of many cancers and other chronic diseases. Making sense of this complex network of interactions requires an assessment of these factors at the population-level. Data and biosamples from the Canadian Partnership for Tomorrow Project (CPTP) - Canada's largest longitudinal population health cohort – are available for request to support research on how these risk factors contribute to disease pathways.
Over 300,000 Canadians aged 30-74 years have joined CPTP; they were recruited from five regional cohorts—BC Generations Project, Alberta’s Tomorrow Project, Ontario Health Study, Quebec’s CARTaGENE, and Atlantic PATH. Each participant completed a baseline questionnaire that includes information on socio-demographic characteristics, personal and family history of disease, medication use, lifestyle and health behaviours, environmental exposures, physical measures and several other details about themselves. Large subsets of participants have provided biological samples, which include venous blood samples (nearly 150,000) urine samples (101,000), and toenail clippings (30,000).
The participants have also provided consent to their regional cohort to link their information with health administrative databases, to be re-contacted to provide an update on their health status, respond to new questionnaires or to take part in additional sub-studies. This information will enrich the CPTP database and provide longitudinal data on the participants.
The CPTP database will also be enriched with data derived from the biological samples. A subset of samples is being analyzed to provide genotyping data and biomarkers of inflammation and those data will become available alongside the CPTP questionnaire data in the near future.
CPTP collaborated with Maelstrom Research to initiate the Cross-Cohort Harmonization Project for Tomorrow (CHPT), a catalogue of searchable metadata on over 2.5 million participants from 13 large cohorts from around the world (>50,000 participants), including CPTP. This project will provide a powerful research tool focused on understanding the risk factors that contribute to cancer and chronic disease.